ABSTRACT
To test the hypothesis that an increased plasma concentration of sialic acid, a marker of the acute-phase response, is related to the presence of diabetic retinopathy in type 1 diabetes mellitus or Insulin Dependent Diabetes Mellitus [IDDM].We investigated the relationship between plasma sialic acid concentration and diabetic retinopathy in a cross-sectional survey of 1,369 people with type 1 diabetes. Subjects were participants in the IDDM Complications Study, which involved diabetic centers of four different hospitals in Lahore. There was a significantly increasing trend of plasma sialic acid with severity of retinopathy [PSubject(s)
Humans
, Male
, Female
, Diabetic Retinopathy/diagnosis
, N-Acetylneuraminic Acid/adverse effects
, Cross-Sectional Studies
, Serum Albumin
, Risk Factors
, Triglycerides
, Cholesterol
, Glycated Hemoglobin
, Hypertension
, Smoking
, Diabetic Angiopathies
, Diabetic Nephropathies
, N-Acetylneuraminic Acid/blood